According to reports, more British entrepreneurs are setting up in northern cities.
The study shows that recovery and growth is happening outside the south-east and new firms tend to pop up close to good universities.
Barclays chief executive Antony Jenkins said: "Entrepreneurs will thrive across the UK if conditions are put in a place that allows them to do so.
"This research shows that business, the education sector and government can all do more to create thriving entrepreneurial ecosystems across the UK.
"The northern corridor is an example of a successful hub establishing itself outside London and the South East. The challenge now is for all interested parties to do more to create those conditions elsewhere. A thriving entrepreneurial industry in the UK will create jobs and growth and have a knock-on effect to the wider UK economy. It has to be a good thing."
The report surveyed experts across industry, academia, business and government about what is needed to support an innovation system in the UK.
The report also established that entrepreneurialism is something that can be created with the right mix of skills, opportunity, access and confidence, and is not something that people are "born" with.
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